Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone (GH) releasing activity. It’s formally known as a growth hormone secretagogue – a compound that is not a growth hormone itself, but promotes and triggers the production of growth hormone in the human pituitary. In the case of ipamorelin, it also acts as a ghrelin/growth hormone secretagogue receptor agonist.
IPAMORELIN Pre Mixed Peptide pen
- Manufactured by: Hyghgh Biopharm Co., Ltd.
- Country of origin: China
- Manufactured since: 2009 – Present
- Package :5mg /3ml /1 pen box
- Price: $1.3 – $3 per IU
- Minimum Order:1 kits
- Storage:2–8 ℃ in room temperature
- Delivery: 5-15 days
- Source: tophygetropin.com/shop/
Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would affect many biological processes. Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells. Unlike other GH releasing peptides, ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone.
IPAMORELIN Peptide benefit & effect
The effects of iPamorelin are simple, to increase natural GH production in the body. It is the increase in GH production that produces the positive benefits and effects the athlete might be after. Increased levels of GH will improve the metabolism thereby giving the individual a greater ability to burn fat or maintain a suitable fat level when trying to grow. More importantly, elevated GH levels, especially stable elevated GH levels help with recovery perhaps more than anything else. Whether we are bulking or cutting it is in the recovery stage that we improve. Recovery helps us build new lean tissue and it helps protect our existing lean tissue.
Most iPamorelin users should also find sleep is deeper and more efficient. Many users report a better mood, which is probably due to the fact that they’re getting more out of their rest. And as with anything that increases GH levels in the body we have the anti-aging benefits. GH affects nearly all parts of the body from muscle to the skeletal structure, nervous system, skin and even hair. GH has often been called the fountain of youth hormone, and it’s not hard to understand why. When we reach our 30’s our natural GH production rapidly declines and continues to decline, and as a result we begin to age. If GH levels remain elevated, while we can’t prevent aging we can slow the effects down.
Important note: iPamorelin will not give as big of a boost in GH levels as HGH. However, HGH is extremely expensive, often hard to get and often counterfeited. iPamorelin, while not as effective as HGH is still better than no increase in GH levels and is one of the best GHRP options available today.
So Ipamorelin stimulates the release of growth hormone in a very selective way. The research on the benefits of ipamorelin is summarized as follows:
Increase bone density (Svensson et al., 2000)
Increases body fat loss in obese adults (Kim et al, 1999)
Increased muscle mass (Andersen et al, 2001)
While Ipamorelin is difficult to access, there are a small handful of online clinics where patients can buy Ipamorelin Injections online.
IPAMORELIN Peptide side effect
There are side effects, possible side effects of iPamorelin use, but it is one of the friendliest growth hormone or growth hormone related medications on the market. iPamorelin, while used by many athletes is not an anabolic steroid. This means side effects of iPamorelin are not anabolic steroid related.
There are no estrogenic side effects of iPamorelin. Gynecomastia cannot occur due to the use of this medication. Water retention cannot occur due to elevated estrogen since estrogen cannot be elevated. However, it is possible, especially during the early stages of use to experience slight water retention; the ankles and wrist are the most common areas.
There are no androgenic side effects of iPamorelin. This GHRP cannot cause acne, hair loss or virilization symptoms in women.
There are no known cardiovascular side effects of iPamorelin. Many users report improved cardiovascular health.
iPamorelin will not suppress natural testosterone production. It will not affect your production of Luteinizing Hormone (LH) or Follicle Stimulating Hormone (FSH). Further, iPamorelin will have no affect on Thyroid Stimulating Hormone (TSH)
iPamorelin is not toxic to the liver at any dose.
Although not highly common, possible side effects of iPamorelin most often occur during the early stages of use. You may or may not need to adjust your dose in order to find a suitable level. Possible side effects include:
- Light Headed (diet adjustments may help)
- Headache (diet adjustments may help)
- Increased levels of prolactin (very rare – Cabergoline can help if needed)
- Redness, itchiness, or irritation at the injection site, which usually is temporary
- Increased appetite/hunger (though this can also be due to the net effect of a boosted metabolism and more muscle mass gains)
- Dry mouth
- Increased weight (Johansen, et al, 1999)
- Excessive water retention may occur but is rare when used as per proper dosing instructions. It’s a common symptom of an overdose or taking too much ipamorelin, however.
Contraindications for usage may exist if you take certain existing medications or supplements, especially those that work on the same biological pathways as ipamorelin. This is why it is critical to discuss ipamorelin’s use, along with any existing medications, supplements, vitamins, or herbal remedies, as part of your consultation with your doctor, healthcare provider, or telemedicine provider, prior to seeking a prescription for ipamorelin or beginning an ipamorelin regimen.
How To Use The IPAMORELIN ?
Ipamorelin is available in injectable forms. You will get the ipamorelin in lyophilized form (powder form) in the vials.
Depending on your dosage guidelines, ipamorelin will have to be mixed with the bacteriostatic water to get the reconstituted ipamorelin.
Once the injectable form is ready, you will have to administer ipamorelin intramuscularly or subcutaneously, i.e., inject it under the skin for maximum results. Most people inject it into the abdominal area.
For faster recovery, it is advisable to inject in close proximity to injured areas.
The dosage guidelines differ a bit depending on the purpose of intake. But it is important to start with a low dosage and then increase gradually.
If you plan to use ipamorelin to meet your fitness goals, you can inject ipamorelin up to 3 times a day with each administration comprising 200mcg-300mcg of ipamorelin.
If your goal is to use ipamorelin as an anti-aging peptide, use it once a day with approximately 200mcg of ipamorelin.
Although higher ipamorelin levels will substantially increase growth hormone levels (GH), you still wouldn’t want to overdose.
Although you can take ipamorelin any time of the day, it is advisable to use ipamorelin before a few hours of going to bed. This sets up a natural timer of growth hormone (GH) release and helps in deep sleep.
Your first cycle should be somewhere between 60 to 90 days. If you start witnessing the changes in your physical features, end your first cycle at the 60-day mark.
You may continue it for up to 90 days if any major changes aren’t seen in the body.
Before kicking off a new cycle, take a month’s break. This is important because it will minimize the chances of receptor desensitization.
Many users use ipamorelin with other similar peptides such as sermorelin and CJC-1295 to have synergistic benefits.
The stacking of ipamorelin with sermorelin can enhance the effects on the body. Increased lean muscle, extremely efficient recovery, a considerable decrease in body fat, and improved sexual performance are the few optimal benefits seen in the body.
Ipamorelin and CJC-1295 have shown better results together. This stacking builds your muscle significantly while at the same time cutting down body fat. You experience an overall boost in your body’s natural performance.
Due to proven benefits, stores like behemoth labz offer stacked products such as Sermorelin/Ipamorelin (5mg/5mg) and CJC-1295 WITH DAC 2mg IPAMORELIN 2mg GHRP-2 2mg BLEND.
How IPAMORELIN Peptide works?
Ghrelin, a naturally produced hormone, is mainly produced in the stomach. It binds to one of the growth hormones secretagogue receptors (GHSR), known as type GHS-R1a.
Although these receptors are predominantly located in the hypothalamus, some of them also lie peripherally, such as on adipocytes, cardiomyocytes, osteoblasts, etc.
The end goal of ipamorelin is to cause the natural release of growth hormone from the anterior lobe of the pituitary gland.
Thus, Ipamorelin achieves this by mimicking the action of ghrelin as it binds to these highly selective growth hormone secretagogue receptor type 1a (GHS-R1a). This binding results in the secretion of somatocrinin also called growth hormone-releasing hormone (GHRH).
Growth hormone-releasing hormone (GHRH) travels to the pituitary gland and causes the pulsatile growth hormone (GH) release.
Ipamorelin also suppresses somatostatin expression, which is called growth hormone inhibiting hormone (GHIH). Hence, blood growth hormone (GH) levels continue to rise.
In this way, ipamorelin continues the homeostatic coordination between hypothalamus-pituitary-somatostatin.
Ipamorelin doesn’t stimulate other endocrine releases such as prolactin and cortisol levels (a stress hormone), making it an ideal peptide for bodybuilders.
This is where ipamorelin comes into play. Direct treatment with human growth hormone has significant side effects. Providing synthetic growth hormone directly into the body is not a natural process, causes spikes and uneven levels of hormone circulating in your system, and greatly increases the likelihood of side effects, up to and including serious side effects such as increased cancer risk (Erotokritou-Mulligan et al., 2011). This is not dissimilar from other forms of hormone treatment, such as estrogen or testosterone treatments, in terms of the direct hormone link.
Peptides like ipamorelin are different, however, in that they aren’t hormones themselves. Rather, by mimicking the action of certain triggering molecules and hormones, such as ghrelin, they trigger the body – specifically the pituitary gland – to produce and release its own natural growth hormones, in a consistent, stable way. This reduces or eliminates the vast majority of the side effects as compared to direct hormonal treatment. That’s one of the main reasons anti-aging peptides have become so popular – you get the benefits of hormonal replacement or treatment without significant known risks.
Why choice the Ipamorelin for bodybuilding and weight loss?
Considering all the potential benefits such as building and bulking up muscles, a robust skeletal system, and faster recovery, this peptide is perfect for bodybuilders and athletes who want to boost their performance in their respective sport.
People who find the aging process a bit daunting can also use ipamorelin as it triggers higher blood growth hormone (GH) levels after the late ’30s can still make you feel youthful.
Also, people who want to lose weight should take ipamorelin as it causes fat loss.
Injection Sites :Where To Injection The Ipamorelin Peptide ?
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. Ipamorelin can also be taken orally.
For faster recovery, it is advisable to inject in close proximity to injured areas.
How to Mix Ipamorelin Peptide?
- Add 1mL of sterile water to the Peptide vial.
- Release the water slowly and strictly on the side of the glass vial.
- DON’T SHAKE the vial violently as this will disrupt the solution.
- Continue to swirl until all the powder dissolves to achieve a clear solution.
- For the Ipamorelin peptide pre mixed pen,Use it directly.
Storage Of The Ipamorelin Peptide
After reconstitution, Hexarelin should be stored at 4°C between 2-7 days and for future use below -18°C.
The Ipamorelin Mixed reviews Summary
If you are a bodybuilder, an athlete, or a fitness pro, your goal is always to stay ahead in the game. You aim to beat your competitors in all aspects. You aspire to climb the ladder to an expert badge as soon as possible.
To make your journey obstacle-free, you start using various peptides without knowing much about them. While most peptides do offer a wide array of benefits, some of them have severe side effects in the long run.
Let’s review one such peptide, Ipamorelin, a growth hormone-releasing peptide (GHRP) whose popularity has grown in recent times. The existing research shows considerable evidence that ipamorelin causes a spike in growth hormone (GH) levels.
I will make sure to cover all the details necessary for you, such as how it works, the potential benefits, the risk factors, and the best places to purchase so that you can decide whether to use it or not. So, let’s cut the slack!
Ipamorelin Peptide review
- Cost Effectiveness