Ara-290 10mg 10vials

Description

Therapeutic Effects of Ara-290 Our peptides are produced exclusively for laboratory and scientific research purposes

ARA-290

How It Works

The biological activity of ARA-290 centers on its interaction with the innate repair receptor, a heteromeric complex composed of the EPO receptor (EPOR) and the common beta receptor (CD 131).

Unlike full-length EPO, which activates both hematopoietic and tissue-protective pathways, ARA-290 selectively targets the tissue-protective pathway through this specific receptor configuration. Research has demonstrated that IRR activation triggers a cascade of intracellular signaling events that promote cellular survival and repair.

The primary signaling pathway involves activation of Janus kinase 2 (JAK 2), which subsequently phosphorylates signal transducer and activator of transcription proteins, particularly STAT 3 and STAT 5.

These transcription factors then migrate to the nucleus, where they initiate expression of genes involved in cell survival, anti-apoptotic responses, and tissue repair processes.

Studies using various cell culture models have shown that ARA-290 treatment leads to increased expression of anti-apoptotic proteins such as Bcl-2 and Bcl-x L, while simultaneously reducing pro-apoptotic factors like Bax and caspase-3 activation.

ARA-290 research also influences the expression of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which play crucial roles in nerve regeneration and maintenance. The anti-inflammatory effects of ARA-290 appear to involve modulation of nuclear factor-kappa B (NF-??B) signaling.

Research indicates that IRR activation leads to suppression of NF-??B translocation to the nucleus, resulting in decreased production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-???), interleukin-1 beta (IL-1??), and interleukin-6 (IL-6).

Simultaneously, ARA-290 research promotes the release of anti-inflammatory mediators, creating a more favorable environment for tissue repair and regeneration.

Product Specifications

• Contents: 10mg 10vials
• Appearance: Lyophilized powder
• Storage: 2-8??C (refrigerated)

How to Use & Administration

All in-stock orders placed before our daily cutoff are shipped the same day from within the United States.

Safety & Research Considerations

Storage & Handling

Store lyophilized peptide powder in a cool, dry place at 2-8 degree C (refrigerate). After reconstitution with bacteriostatic water, keep refrigerated and use within the recommended timeframe. Protect from light and moisture. Do not freeze the reconstituted solution. Keep the product in its original packaging until ready for use.

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Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. For laboratory research use only.